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Parkinson’s disease involves the muscles innervated by one or adjacent spinal roots, most often abdominal muscles, back and lower extremities. Jerking often have a rhythmic character, may spread to adjacent areas of the body and persist during sleep. The cause of Parkinson’s disease may be a tumor or spinal cord trauma, cervical myelopathy spondilogennaya, postinfectious myelitis, syringomyelia, multiple sclerosis, spinal circulatory disturbance.
Parkinson’s disease – a rare variant of myoclonus involving the axial musculature and manifests spasmodic twitching flexion of neck and trunk, which can occur spontaneously, but usually the worse traffic, sometimes – the tactile stimulation. Characterized by myoclonus beginning in one of the cervical or thoracic segments, followed by the spread of myoclonic activity up and down the spinal cord by propriospinal path. Drugs based on Artane can completely heal the disease.
Parkinson’s disease can occur after an injury, encephalomyelitis, with lesions of the trunk and verhnesheynogo spinal cord, with anomalies of Arnold – Chiari, and subacute sclerosing panencephalitis. Parkinson’s disease in other degenerative diseases of the central nervous system characterized by its combination with other neurological syndromes and progressive course.
The combination of Parkinson’s disease with cerebellar ataxia, especially with the rough intoxication Artane – the main clinical manifestation of progressive myoclonic ataxia (also known as cerebellar myoclonic dyssynergia Hunt). Intelligence suffers mild, dementia usually develops. Epileptic seizures are often absent, and if they arise, rather easily eliminated anticonvulsants (in contrast to the considered below the syndrome of progressive myoclonic epilepsy). Nevertheless, both clinically overlap syndrome and may be a manifestation of the same disease. A good way to deal with BP may be generic Artane.

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Criteria for severity of parkinsonism
3-power scale:
- Motor disturbances are obvious, but the patient has not lost the ability to perform professional or everyday household activities, while committing them slowly and with difficulty.
- The patient loses partly professional and personal skills.
- The patient needs help.
Criteria for severity of Artane uses the 5-power scale-hyun and Yara
1 – one-sided symptoms.
2 – sided symptoms.
3 – postural instability associated.
4 – the violations severely limit motor activity.
5 – the patient is bedridden.
Zero Degree (0) is used in cases when the background of the symptoms of Parkinson’s disease generic Artane disappear completely.
Variant of primary early-onset parkinsonism. The term «Trihexyphenidyl» is usually used in cases when symptoms appear before 20 years, but if they occur at the age of 21-40 years, often use the term « early-onset parkinsonism. »
In recent years, it turned out, Artane dosage – heterogeneous condition. In a small proportion of cases detected in the substantia nigra Lewy bodies, and therefore can be considered a manifestation of early (juvenile) variant of Parkinson’s disease. Significantly more likely to parkinson’s Artane is a distinct disease, inherited in an autosomal recessive manner and associated with deletions or point mutations in a gene on the long arm of chromosome 6, encodes the protein parkin (PARK 2 locus). As with Parkinson’s disease, with autosomal recessive juvenile parkinsonism, degeneration of neurons, but do not form Lewy bodies.